Journal: bioRxiv
Article Title: Cancer pathway connectivity resolved by drug perturbation and RNA sequencing
doi: 10.64898/2025.12.11.692401
Figure Lengend Snippet: a , Dose-response curves of 20 patients treated with IRAK4 inhibitor and IRAK4 inhibitor combined with 1 µg/mL CpG-ODN for TLR9 stimulation. b , Gene expression of genes on the amplified locus chr12:42,538,673-chr12: 44,229,999 (hg19) by trisomy 12 status for the CLL cohort (n = 210) from Lütge et al. . Significance levels were calculated using two-tailed Student’s t -test and shown as nominal P -values.
Article Snippet: For the CpG stimulation, cells were supplemented with 1.25 μg/mL of the TLR9 agonist ODN2006 (InvivoGen) before seeding to reach a final assay concentration of 1 μg/mL.
Techniques: Gene Expression, Amplification, Two Tailed Test